Spermatogonial Stem Cell Transplantation in Large Animals
نویسندگان
چکیده
منابع مشابه
Advances in spermatogonial stem cell transplantation.
Spermatogonial stem cell transplantation was first reported by Ralph Brinster's laboratory in 1994. It has proven to be a technological breakthrough in the study of both stem cells and Sertoli cell-germ cell interactions. This technique can be used to transfer testicular stem cells successfully from one animal to another of the same species (referred to as syngeneic transplants) and sometimes t...
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BACKGROUND Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, and reside within a specific microenvironment in the testes called "niche" which regulates stem cell properties, such as, self-renewal, pluripotency, quiescence and their ability to differentiate. METHODOLOGY/PRINCIPAL FINDINGS Here, we introduce zebrafish as a new model for the study of SSCs in vertebrates. Us...
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The past 30 years have been marked by unparalleled accomplishments in the medical treatment of malignancy. Prior to advances in chemotherapeutic and radiation treatment, many oncologic conditions had dismal survival rates. Today, medical interventions have success rates that approach complete remission for many malignancies. An inadvertent complication of these therapies, however, has been the ...
متن کاملMelatonin improves spermatogonial stem cells transplantation efficiency in azoospermic mice
Objective(s):Transplantation quality improvement and reduction of cellular damage are important goals that are now considered by researchers. Melatonin is secreted from the pineal gland and some organs such as testes. According to beneficial effects of melatonin (such as its antioxidant and antiapoptotic properties), researchers have proposed that the use of melatonin may improve transplantatio...
متن کاملSpermatogonial Stem Cell Transplantation from a Horse to a Mule
Spermatogonial stem cell transfer has been studied in various species and suggested potential for success. Bull, stallion, donkey, mule, boar, dog and cat testicles were examined using various injection techniques to determine distribution patterns of injected material most favorable for stem cell transfer. Spermatogonial stem cells were recovered from freshly harvested stallion testicles using...
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ژورنال
عنوان ژورنال: Animals
سال: 2021
ISSN: 2076-2615
DOI: 10.3390/ani11040918